Aneuploid deoxyribonucleic acid content of human carcinomas

ABSTRACT THE basic question of whether primary human malignant tumours consist of euploid or aneuploid cells has so far remained unanswered. It has been possible to determine the chromosome

complement and deoxyribonucleic acid content only of human carcinomas with cells exfoliated in ascitic fluid1,2, human carcinomas transplanted in rats and hamsters3 and carcinomas grown in

tissue culture.4,5 This lack of information can be attributed to several technical difficulties. Chromosome counts on solid human tumours cannot be generally obtained since a pretreatment

with colchicine is impossible. The deoxy ribonucleic acid measurement by the one-wave-length method has so far been limited to interphase nuclei6 in which the occurrence of deoxyribonucleic

acid synthesis prevents any conclusions in regard to euploidy or aneuploidy. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in

* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ANEUPLOIDY AS A PROMOTER AND SUPPRESSOR OF MALIGNANT GROWTH

Article 11 January 2021 NORMAL BREAST TISSUES HARBOUR RARE POPULATIONS OF ANEUPLOID EPITHELIAL CELLS Article 20 November 2024 CLONAL ORIGIN AND DEVELOPMENT OF HIGH HYPERDIPLOIDY IN CHILDHOOD

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(1959). Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Saskatchewan Research Unit of the National Cancer Institute of Canada, and Department of Cancer

Research, University of Saskatchewan, H. F. STICH * Department of Pathology, University Hospital, University of Saskatchewan, Saskatoon, Sask H. E. EMSON Authors * H. F. STICH View author

publications You can also search for this author inPubMed Google Scholar * H. E. EMSON View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE STICH, H., EMSON, H. Aneuploid Deoxyribonucleic Acid Content of Human Carcinomas. _Nature_ 184, 290–291 (1959).

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