Ethyl ω-Fluoroacetoacetate | Nature

ABSTRACT ACETOACETIC acid is an important and widespread intermediary metabolite, being formed in the oxida-tive degradation of fatty acids and of certain amino-acids. For comparison with

acetoacetic acid, we have prepared1 the compound ethyl ω-fluoroacetoacetate, FCH2COCH2COOC2H5. From a consideration of its structural similarity to 4-fluorobutyric acid2 and of its probable

interference with the mechanism of fatty acid metabolism, we predicted that it would produce toxic symptoms. Access through your institution Buy or subscribe This is a preview of

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FLUOROSULFONYLATION OF ALKENES Article Open access 13 December 2023 ENZYMATIC SYNTHESIS OF MONO- AND TRIFLUORINATED ALANINE ENANTIOMERS EXPANDS THE SCOPE OF FLUORINE BIOCATALYSIS Article

Open access 09 May 2024 A WAY TO THIOACETATE ESTERS COMPATIBLE WITH NON-OXIDATIVE PREBIOTIC CONDITIONS Article Open access 02 September 2020 REFERENCES * Pattison, F. L. M., Interim Report

No. 8 (June 1954). * Pattison, F. L. M., _Nature_, 172, 1139 (1953). Article  ADS  CAS  Google Scholar  * Bowman, R. E., and Fordham, W. D., _J. Chem. Soc._, 3945 (1952). Download references

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Chemistry, University of Western Ontario, London, Canada R. R. FRASER & F. L. M. PATTISON Authors * R. R. FRASER View author

publications You can also search for this author inPubMed Google Scholar * F. L. M. PATTISON View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE FRASER, R., PATTISON, F. Ethyl ω-Fluoroacetoacetate. _Nature_ 176, 696 (1955). https://doi.org/10.1038/176696a0

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