Human parvovirus b19 infection with gvhd-like erythema in two allogeneic stem cell transplant recipients

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Human parvovirus b19 infection with gvhd-like erythema in two allogeneic stem cell transplant recipients"


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Access through your institution Buy or subscribe We report two cases of human parvovirus B19 infection as a rare but anticipated complication shortly after allogeneic peripheral blood stem


cell transplantation (PBSCT), which were self-limiting in their course. The first patient was a 48-year-old female treated for secondary acute myeloid leukaemia (AML) FAB M2 following


chemotherapy for breast cancer 7 years ago. She received a PBSCT in second complete remission, from a matched unrelated donor, after conditioning with 2 Gy total-body irradiation, 120 mg/m2


fludarabine, 60 mg/kg cyclophosphamide and 30 mg/kg antithymocyte globulin. Immunosuppressive therapy was initiated with cyclosporine and mycofenolate. One day before transplantation, the


patient presented with sudden skin erythema, which soon resolved without any treatment. On day 10 after PBSCT, she developed an erythematous itchy eruption of the skin on both arms and the


neck line, initially reminiscent of acute graft-versus-host disease (aGvHD), but subsequently very inconsistent in its appearance in that it migrated from the neck line to the abdomen and


back and finally to both legs. This lasted for a period of 14 days. Our differential diagnosis included early acute cutaneous GvHD, viral erythema and drug-induced erythema. The latter


seemed unlikely as no new drug had been administered. To clarify the diagnosis a skin biopsy was taken. Surprisingly, this turned out to be positive for parvovirus B19 upon polymerase chain


reaction (PCR), as was a bone marrow aspirate (700 copies/ml) taken at the same time. PCR from skin samples were not analysed quantitatively. Histology did not show any signs suggestive of


GvHD but a nonspecific pattern of inflammation with distinct signs of cytotoxicity, as is frequently seen in skin lesions because of viral infections. Blood was positive for parvovirus B19


immunoglobin G (IgG) before transplantation. Findings were negative for parvovirus B19 IgM before, during and after the infection. Parvovirus B19 PCR in peripheral blood was also negative


during and after the infection. This is a preview of subscription content, access via your institution RELEVANT ARTICLES Open Access articles citing this article. * GRAFT-VERSUS-LYMPHOMA


EFFECT IN A 64-YEAR-OLD CAUCASIAN WOMAN AFTER ALLOGENEIC STEM-CELL TRANSPLANTATION: A CASE REPORT * Gerhard Behre * , Thomas Weber *  … Maximilian Christopeit _Journal of Medical Case


Reports_ Open Access 13 January 2009 ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue


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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Ang HA, Apperley JF, Ward KN . Persistence of antibody to human


parvovirus B19 after allogeneic bone marrow transplantation: role of prior recipient immunity. _Blood_ 1997; 89: 4646–4651. CAS  PubMed  Google Scholar  * Brown KE, Young NS . Parvovirus B19


infection and hematopoiesis. _Blood Rev_ 1995; 9: 176–182. Article  CAS  Google Scholar  * Solano C, Juan O, Gimeno C, Garcia-Conde J . Engraftment failure associated with peripheral blood


stem cell transplantation after B19 parvovirus infection. _Blood_ 1996; 88: 1515–1517. CAS  PubMed  Google Scholar  * Heegaard ED, Petersen BL . Parvovirus B19 transmitted by bone marrow.


_Br J Haematol_ 2000; 111: 659–661. Article  CAS  Google Scholar  * Plentz A, Hahn J, Knöll A, Holler E, Jilg W, Modrow S . Exposure of hematologic patients to parvovirus B19 as a


contaminant of blood cell preparations and blood products. _Transfusion_ 2005; 45: 1811–1815. Article  Google Scholar  * Bonvicini F, Gallinella G, Gentilomi GA, Ambretti S, Musiani M,


Zerbini M . Prevention of iatrogenic transmission of B19 infection: different approaches to detect, remove or inactivate virus contamination. _Clin Lab_ 2006; 52: 263–268. PubMed  Google


Scholar  * Eid AJ, Brown RA, Patel R, Razonable RR . Parvovirus B19 infection after transplantation: a review of 98 cases. _Clin Infect Dis_ 2006; 43: 40–48. Article  Google Scholar  *


Hayes-Lattin B, Seipel TJ, Gatter K, Heinrich MC, Maziarz RT . Pure red cell aplasia associated with parvovirus B19 infection occurring late after allogeneic bone marrow transplantation. _Am


J Hematol_ 2004; 75: 142–145. Article  Google Scholar  * Mouthon L, Guillevin L, Tellier Z . Intravenous immunglobulins in autoimmune- or parvovirus B19 pure red cell aplasia. _Autoimmun


Rev_ 2005; 4: 264–269. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Internal Medicine IV, Bone Marrow Transplantation


Section, Hematology and Oncology, State Center for Cell and Gene Therapy, Martin-Luther-University Halle-Wittenberg, Halle, Germany A Muetherig, M Christopeit, L P Müller, W Grothe, T Weber,


 S Theurich & G Behre Authors * A Muetherig View author publications You can also search for this author inPubMed Google Scholar * M Christopeit View author publications You can also


search for this author inPubMed Google Scholar * L P Müller View author publications You can also search for this author inPubMed Google Scholar * W Grothe View author publications You can


also search for this author inPubMed Google Scholar * T Weber View author publications You can also search for this author inPubMed Google Scholar * S Theurich View author publications You


can also search for this author inPubMed Google Scholar * G Behre View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to


G Behre. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Muetherig, A., Christopeit, M., Müller, L. _et al._ Human parvovirus B19 infection with


GvHD-like erythema in two allogeneic stem cell transplant recipients. _Bone Marrow Transplant_ 39, 315–316 (2007). https://doi.org/10.1038/sj.bmt.1705589 Download citation * Published: 21


February 2007 * Issue Date: March 2007 * DOI: https://doi.org/10.1038/sj.bmt.1705589 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get


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