Severe regimen-related toxicity of second transplantation for graft failure following reduced-intensity cord blood transplantation in an adult patient

Access through your institution Buy or subscribe Graft failure represents a serious complication after allogeneic stem cell transplantation (allo-SCT).1 Such failure comprises two clinical

entities: primary graft failure and graft rejection.2 Three treatment options are available for primary graft failure: administration of hematopoietic growth factor; booster infusion of

donor hematopoietic stem cells; or infusion of previously harvested autologous hematopoietic stem cells.1 In the management of graft rejection, further immunosuppressive conditioning is

necessary before second infusion of hematopoietic stem cells.1 Some recent reports have demonstrated the feasibility of cord blood transplantation (CBT) using reduced-intensity regimens

(RI-CBT) for adult patients with advanced hematological disease.3, 4 Graft failure is a significant complication associated with high mortality in both RI-CBT.5 Narimatsu _et al._5 reported

that nine of 123 patients developed graft failure and four patients underwent second RI-CBT and developed severe regimen-related toxicities (RRTs) following a conditioning regimen of

fludarabine 125 mg/m2, either melphalan 80 mg/m2 or busulfan 8 mg/kg, and 2–4 Gy total body irradiation (TBI). This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Georges G, Storb R . Failure of sustained engraftment: clinical manifestations and treatment. In: Atkinson

K (ed). _Clinical Bone Marrow and Blood Stem Cell Transplantation_, 3rd edn. Cambridge University Press: Cambridge, UK, 2000, pp 1088–1188. Google Scholar  * Hows JM . Mechanisms of graft

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73–77. CAS  PubMed  Google Scholar  * Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C _et al_. Transplantation of unrelated donor umbilical cord blood in 102 patients with

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_Blood_ 1997; 89: 1818–1823. CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Hematology and Oncology, JA Aichi Showa Hospital,

Konan, Japan K Shimada, H Narimatsu, Y Morishita, A Kohno, S Saito & Y Kato * Department of Hematology, Toyohashi Municipal Hospital, Toyohashi, Japan H Narimatsu Authors * K Shimada

View author publications You can also search for this author inPubMed Google Scholar * H Narimatsu View author publications You can also search for this author inPubMed Google Scholar * Y

Morishita View author publications You can also search for this author inPubMed Google Scholar * A Kohno View author publications You can also search for this author inPubMed Google Scholar

* S Saito View author publications You can also search for this author inPubMed Google Scholar * Y Kato View author publications You can also search for this author inPubMed Google Scholar

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Shimada, K., Narimatsu, H., Morishita, Y. _et al._ Severe regimen-related toxicity of second

transplantation for graft failure following reduced-intensity cord blood transplantation in an adult patient. _Bone Marrow Transplant_ 37, 787–788 (2006).

https://doi.org/10.1038/sj.bmt.1705312 Download citation * Published: 27 February 2006 * Issue Date: 01 April 2006 * DOI: https://doi.org/10.1038/sj.bmt.1705312 SHARE THIS ARTICLE Anyone you

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