Total parenteral nutrition vs oral diet in autologous hematopoietic cell transplant recipients

SUMMARY: Autologous HCT patients often have poor oral intake for 2–4 weeks post transplant. To compare outcomes between patients provided prophylactic total parenteral nutrition (TPN) or an

oral diet (OD), 55 well nourished breast cancer/ hematopoietic cell transplantation (HCT) patients were randomized to TPN (_n_=27), beginning day −1, or OD (_n_=28). Parameters studied

include length of stay (LOS), engraftment, infections, survival, weight, anthropometrics, handgrip strength, and quality of life (QOL) In all, 50% of OD patients were given TPN due to poor

oral intake for 10 consecutive days. No significant differences were found between the groups for any of the above parameters except weight and anthropometrics, which were better maintained

in the TPN group than the OD group. Trends were seen for increased infections, more stable handgrip strength, and improved QOL in the TPN group _vs_ the OD group. Prophylactic TPN did result

in a more intact nutritional status and preservation of lean body mass post transplant but did not impact LOS or survival when compared to OD. For this reason, TPN should be reserved for

autologous HCT patients with pretransplant nutritional depletion, complications post transplant, or prolonged poor oral intake. These results should not be extrapolated to allogeneic HCT

patients but are likely applicable to other well nourished autologous HCT patients. Access through your institution Buy or subscribe This is a preview of subscription content, access via

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HEMATOPOIETIC CELL TRANSPLANTATION Article 10 October 2020 NUTRITION SUPPORT AND CLINICAL OUTCOMES FOLLOWING ALLOGENEIC STEM CELL TRANSPLANTATION Article 04 August 2023 IMPROVING NUTRITIONAL

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INFORMATION AUTHORS AND AFFILIATIONS * Baylor University Medical Center, Dallas, TX, USA S Roberts, L Pineiro & L Jennings * Meredith Corporation, Des Moines, Iowa, USA J Miller Authors

* S Roberts View author publications You can also search for this author inPubMed Google Scholar * J Miller View author publications You can also search for this author inPubMed Google

Scholar * L Pineiro View author publications You can also search for this author inPubMed Google Scholar * L Jennings View author publications You can also search for this author inPubMed 

Google Scholar CORRESPONDING AUTHOR Correspondence to S Roberts. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Roberts, S., Miller, J., Pineiro, L. _et

al._ Total parenteral nutrition _vs_ oral diet in autologous hematopoietic cell transplant recipients. _Bone Marrow Transplant_ 32, 715–721 (2003). https://doi.org/10.1038/sj.bmt.1704204

Download citation * Received: 13 October 2002 * Accepted: 06 April 2003 * Published: 16 September 2003 * Issue Date: 01 October 2003 * DOI: https://doi.org/10.1038/sj.bmt.1704204 SHARE THIS

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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * total parenteral nutrition * autologous * breast cancer * nutritional status