Osteosarcoma after allogeneic bone marrow transplantation. A report of four cases from the cooperative osteosarcoma study group (coss)

SUMMARY: Osteosarcoma, one of the most frequent secondary malignancies after the treatment of young patients with cancer, has only very rarely been observed in association with hematopoietic

stem cell transplantation (HSCT). We report four patients who were identified by searching the database of the Cooperative Osteosarcoma Study Group (COSS) for patients whose osteosarcoma

arose following HSCT. Transplant indications had been acute lymphoblastic leukemia (3) and sickle cell disease (1), and the stem cell source was bone marrow in all cases (three allo-geneic,

one syngeneic). All four had received chemotherapy with alkylators as part of their conditioning regimen and/or first line therapy. The conditioning regimen included total body irradiation

in three patients. The osteosarcomas arose at the age (adolescence) and sites (around the knee) typical for the disease. All four patients received chemotherapy as part of multimodal

osteosarcoma treatment, and all four are currently alive, three in continuous remission at 5 7/12, 2 11/12, and 0 6/12 years and one with relapsed osteosarcoma at 4 1/12 years. One of the

osteosarcoma-free survivors suffered a third malignancy, myelodysplastic syndrome. Osteosarcoma should be included among the secondary malignancies that can arise following HSCT. Multi-modal

therapy according to guidelines for _de novo_ osteosarcoma can lead to long-term survival in selected patients. Access through your institution Buy or subscribe This is a preview of

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TRANSPLANTATION WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE FOR OSTEOPETROSIS AND OTHER NONMALIGNANT DISEASES Article 27 August 2020 OSTEOSARCOMA Article 08 December 2022 DEVELOPMENT OF

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references ACKNOWLEDGEMENTS The COSS studies are supported by Deutsche Krebshilfe. The authors wish to thank M Kevric, S Flege, and B Kempf-Bielack from the COSS-Data Center for their

assistance; A Kretschmann from the ALL-BFM-Relapse Study Center, Berlin, U Rohrberg from the Pediatric University Hospital Aachen, G Fleischhack from the Pediatric University Hospital Bonn,

and M Schrappe from the ALL BFM Study Center, Hannover for valuable information concerning the reported patients; J Whelan, S Ferrari, M Bernstein, and S Smeland for searching for

osteosarcomas post-BMT among the patients from their multi-institutional osteosarcoma groups, and would like to acknowledge the physicians, nurses, data managers, and support staff of the

collaborating centers for their active participation. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatric Hematology and Oncology, University Children's Hospital,

Muenster, Germany S S Bielack, J S Rerin, J Vormoor & H Jürgens * Hematology/Oncology, Johanniter Kinderklinik, St Augustin, Germany R Dickerhoff * Department of Pediatric Hematology and

Oncology, University Children's Hospital, Duesseldorf, Germany D Dilloo * Department of Pediatric Hematology–Oncology and Endocrinology, University Children's Hospital, Essen,

Germany B Kremens * Department of Pediatric Oncology/Hematology, Charité Medical Center, Humboldt-University, Berlin, Germany A von Stackelberg Authors * S S Bielack View author publications

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CONSORTIA FOR THE COOPERATIVE GERMAN–AUSTRIAN–SWISS OSTEOSARCOMA STUDY GROUP COSS RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bielack, S., Rerin, J.,

Dickerhoff, R. _et al._ Osteosarcoma after allogeneic bone marrow transplantation. A report of four cases from the Cooperative Osteosarcoma Study Group (COSS). _Bone Marrow Transplant_ 31,

353–359 (2003). https://doi.org/10.1038/sj.bmt.1703864 Download citation * Received: 12 August 2002 * Accepted: 01 October 2002 * Published: 12 March 2003 * Issue Date: 01 March 2003 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * bone marrow transplantation * neoplasms (second

primary) * osteosarcoma