High incidence of gastrointestinal tract bleeding after autologous stem cell transplant for primary systemic amyloidosis

ABSTRACT Peripheral blood stem cell transplants have been associated with better response rates than conventional chemotherapy in patients with primary systemic amyloidosis. A higher

incidence of gastrointestinal (GI) tract bleeding has been observed among amyloidosis patients undergoing peripheral stem cell transplantation. We retrospectively reviewed the medical

records of such patients to identify those who had GI tract bleeding in the post-transplant period. Forty-five patients were studied. Nine patients had GI tract bleeding in the

post-transplant period. The median post-transplant duration to onset of bleeding was 9.5 days (range 1 to 48 days). Three patients had lower GI tract bleeding, two had upper GI tract

bleeding, and four had both. Diffuse esophagitis and gastritis were the most common findings on endoscopy. There were no correlations among the age, platelet nadir, or CD34 count of the

graft and the risk of bleeding. Women were more likely to have GI tract bleeding (_P_ = 0.015), as were patients with slow platelet engraftment (_P_ = 0.02). Patients with multiorgan

involvement and those on hemodialysis appeared to be at a higher risk of GI tract bleeding. The mean post-transplant hospital stay for those with GI tract bleeding was 37 days compared with

14.5 days for those who did not have GI tract bleeding (_P_ = 0.0047). _Bone Marrow Transplantation_ (2001) 28, 381–385. Access through your institution Buy or subscribe This is a preview of

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Medicine, Mayo Clinic, Rochester, MN, USA S Kumar, A Dispenzieri, MQ Lacy, MR Litzow & MA Gertz Authors * S Kumar View author publications You can also search for this author inPubMed 

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gastrointestinal tract bleeding after autologous stem cell transplant for primary systemic amyloidosis. _Bone Marrow Transplant_ 28, 381–385 (2001). https://doi.org/10.1038/sj.bmt.1703155

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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * GI bleeding * high-dose chemotherapy * stem cell transplantation * systemic amyloidosis