Expression of a free gamma heavy chain in serum following autologous stem cell transplantation for igg kappa multiple myeloma

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Expression of a free gamma heavy chain in serum following autologous stem cell transplantation for igg kappa multiple myeloma"


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ABSTRACT A 41-year-old male with IgG kappa multiple myeloma is described. He developed a free gamma heavy chain without an accompanying light chain following high-dose chemotherapy and


autologous peripheral blood stem cell transplantation. The free gamma heavy chain was detected in serum and urine specimens 2 months after transplant, and eventually evolved into an IgG


kappa monoclonal protein with electrophoretic properties similar to the original myeloma protein. Although the origin of the free gamma heavy chain remains uncertain, it was most likely


related to the underlying plasma cell malignancy and, therefore, was an early sign of disease relapse. _Bone Marrow Transplantation_ (2001) 27, 663–666. Access through your institution Buy


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OTHERS THE SIGNIFICANCE OF FREE LIGHT-CHAIN RATIO IN LIGHT-CHAIN MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: A FLOW CYTOMETRY SUB-STUDY OF THE ISTOPMM SCREENING STUDY Article Open


access 18 December 2024 IMMUNOPHENOTYPIC ASSESSMENT OF CLONAL PLASMA CELLS AND B-CELLS IN BONE MARROW AND BLOOD IN THE DIAGNOSTIC CLASSIFICATION OF EARLY STAGE MONOCLONAL GAMMOPATHIES: AN


ISTOPMM STUDY Article Open access 11 December 2023 MULTIPLE MYELOMA Article 27 June 2024 REFERENCES * Landis SH, Murray T, Bolden S _et al_. Cancer statistics 1999 _CA Cancer J Clin_ 1999


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Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, CA, USA AW


Butch * Myeloma and Transplantation Research Center, University of Arkansas for Medical Sciences, AK, USA AW Butch, A Badros, KR Desikan & NC Munshi * South Central Arkansas Veterans


Health Care System, Little Rock, AK, USA NC Munshi Authors * AW Butch View author publications You can also search for this author inPubMed Google Scholar * A Badros View author publications


You can also search for this author inPubMed Google Scholar * KR Desikan View author publications You can also search for this author inPubMed Google Scholar * NC Munshi View author


publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Butch, A., Badros, A., Desikan,


K. _et al._ Expression of a free gamma heavy chain in serum following autologous stem cell transplantation for IgG kappa multiple myeloma. _Bone Marrow Transplant_ 27, 663–666 (2001).


https://doi.org/10.1038/sj.bmt.1702850 Download citation * Received: 26 September 2000 * Accepted: 07 December 2000 * Published: 23 April 2001 * Issue Date: 01 March 2001 * DOI:


https://doi.org/10.1038/sj.bmt.1702850 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not


currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * multiple myeloma * relapse * autologous stem cell


transplantation * heavy chain protein


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