Expression of a free gamma heavy chain in serum following autologous stem cell transplantation for igg kappa multiple myeloma

ABSTRACT A 41-year-old male with IgG kappa multiple myeloma is described. He developed a free gamma heavy chain without an accompanying light chain following high-dose chemotherapy and

autologous peripheral blood stem cell transplantation. The free gamma heavy chain was detected in serum and urine specimens 2 months after transplant, and eventually evolved into an IgG

kappa monoclonal protein with electrophoretic properties similar to the original myeloma protein. Although the origin of the free gamma heavy chain remains uncertain, it was most likely

related to the underlying plasma cell malignancy and, therefore, was an early sign of disease relapse. _Bone Marrow Transplantation_ (2001) 27, 663–666. Access through your institution Buy

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OTHERS THE SIGNIFICANCE OF FREE LIGHT-CHAIN RATIO IN LIGHT-CHAIN MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: A FLOW CYTOMETRY SUB-STUDY OF THE ISTOPMM SCREENING STUDY Article Open

access 18 December 2024 IMMUNOPHENOTYPIC ASSESSMENT OF CLONAL PLASMA CELLS AND B-CELLS IN BONE MARROW AND BLOOD IN THE DIAGNOSTIC CLASSIFICATION OF EARLY STAGE MONOCLONAL GAMMOPATHIES: AN

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Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, CA, USA AW

Butch * Myeloma and Transplantation Research Center, University of Arkansas for Medical Sciences, AK, USA AW Butch, A Badros, KR Desikan & NC Munshi * South Central Arkansas Veterans

Health Care System, Little Rock, AK, USA NC Munshi Authors * AW Butch View author publications You can also search for this author inPubMed Google Scholar * A Badros View author publications

You can also search for this author inPubMed Google Scholar * KR Desikan View author publications You can also search for this author inPubMed Google Scholar * NC Munshi View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Butch, A., Badros, A., Desikan,

K. _et al._ Expression of a free gamma heavy chain in serum following autologous stem cell transplantation for IgG kappa multiple myeloma. _Bone Marrow Transplant_ 27, 663–666 (2001).

https://doi.org/10.1038/sj.bmt.1702850 Download citation * Received: 26 September 2000 * Accepted: 07 December 2000 * Published: 23 April 2001 * Issue Date: 01 March 2001 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * multiple myeloma * relapse * autologous stem cell

transplantation * heavy chain protein