Virulence-enhancing factor of hog gastric mucin

ABSTRACT FROM the time of the original discovery of the virulence-enhancing power for bacteria of hog gastric mucin by Miller1 and, independently, Nungester2, the effect has been used

extensively in the production of experimental infections of animals, as, for example, in chemotherapeutic and in serum testing (for review, see ref. 3). A large number of different species

of bacteria show enhanced virulence when injected intraperitoneally together with the mucin, and the effect is often striking—a reduction of 104–106 in L.D.50 is frequent. Furthermore, the

effect is not confined to hog gastric mucin: other mucins have been reported active. This suggests that the mucins coating epithelial surfaces may aid pathogenic bacteria in their initial

attack; such a possibility makes the investigation of mucins for a chemical entity producing the effect an interesting problem. Access through your institution Buy or subscribe This is a

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PYLORI_ INITIATES SUCCESSFUL GASTRIC COLONIZATION BY UTILIZING L-LACTATE TO PROMOTE COMPLEMENT RESISTANCE Article Open access 27 March 2023 ROLE OF MUCUS-BACTERIA INTERACTIONS IN

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SECRETION ATTACKS THROUGH IMMUNITY PROTEIN-INDEPENDENT MECHANISMS Article Open access 01 October 2021 REFERENCES * Miller, C. P., _Science_, 78, 340 (1933). Miller, C. P., and Castles, R.,

_J. Infect. Dis._, 58, 263 (1936). Article  ADS  CAS  Google Scholar  * Nungester, W. J., Wolf, A. A., and Jourdonais, L. F., _Proc. Soc. Exp. Biol. and Med._, 30, 120 (1932); _J. Infect.

Dis._, 59, 11 (1936). Article  Google Scholar  * Olitzki, L., _Bact. Rev._, 12, 149 (1948). CAS  Google Scholar  * Anderson, C. G., and Oag, R. K., _Brit. J. Exp. Path._, 20, 25 (1939). CAS

  Google Scholar  * Gould, J. C., and King, H. K., _Biochem. J._, 41, xxi (1947). CAS  PubMed  Google Scholar  * King, H. K., and MacCabe, A. F., _J. Gen. Microbiol._, 3, xi (1949). CAS 

PubMed  Google Scholar  * King, H. K., and Morgan, W. T. J., _Biochem. J._, 37, 640 (1943). Article  Google Scholar  * Annison, E. F., Chadwick, D. W., Morgan, W. T. J., and Smith, H.,

_Nature_, 164, 62 (1949). Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Microbiological Research Department, Porton, Wilts H. SMITH Authors * H. SMITH

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Virulence-enhancing Factor of Hog Gastric Mucin. _Nature_ 165, 77 (1950). https://doi.org/10.1038/165077a0 Download citation * Issue Date: 14 January 1950 * DOI:

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