Five new mouse susceptibility to colon cancer loci, scc11–scc15

ABSTRACT Although several genes causing familial cancer syndromes have been identified, susceptibility to sporadic cancer remains unsolved. Animal experiments have demonstrated a large

number of quantitative trait loci affecting cancer susceptibility. Previously, we described in mouse strain CcS-19/Dem five susceptibility to colon cancer (_Scc_) loci, _Scc1_–_Scc5_

controlling tumor numbers. In the present study, we performed an independent identical mouse cross using a distinct carcinogen, azoxymethane, to induce colon tumors. We confirmed all five

originally described _Scc_ loci and detected five additional new _Scc_ loci; _Scc11_–_Scc15_. All these loci were detected in two-way interactions. Access through your institution Buy or

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MAPPING OF NOVEL LOCI INVOLVED IN LUNG AND COLON TUMOR SUSCEPTIBILITY BY THE USE OF GENETICALLY SELECTED MOUSE STRAINS Article Open access 29 December 2021 PAN-CANCER STUDY DETECTS GENETIC

RISK VARIANTS AND SHARED GENETIC BASIS IN TWO LARGE COHORTS Article Open access 04 September 2020 ASSESSMENT OF POLYGENIC ARCHITECTURE AND RISK PREDICTION BASED ON COMMON VARIANTS ACROSS

FOURTEEN CANCERS Article Open access 03 July 2020 ABBREVIATIONS * AOM: azoxymethane * _Scc_ : susceptibility to colon cancer REFERENCES * Balmain A . (2002). _Cell_, 108, 145–152. * Demant P

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_Nature_, 411, 336–341. * Ruivenkamp C, van Wezel T, Zanon C, Stassen A, Vleck C, Csikós T, Klous A, Tripodis N, Perrakis A, Boerrigter L, Groot P, Lindeman L, Mooi W, Scholten G, Dauwerse

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Res._, 59, 4216–4218. Download references ACKNOWLEDGEMENTS We thank Joost de Moes, Elly Delzenne-Goette, and Marcelle Treur for excellent technical assistance. We appreciate the many

discussions of the statistical analysis with Dr Nikos Tripodis and Dr G Hart. This work was supported by Dutch Cancer Society Grants NKI 97-1436 and NKI 98-1832. AUTHOR INFORMATION Author

notes * Claudia A L Ruivenkamp Present address: Department of Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands * Tom van Wezel

Present address: Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands * Peter Demant Present address: Department of Molecular and Cellular Biology, Roswell Park

Cancer Institute, Buffalo, NY, USA AUTHORS AND AFFILIATIONS * Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands Claudia A

L Ruivenkamp, Tamás Csikós, Anita M Klous, Tom van Wezel & Peter Demant Authors * Claudia A L Ruivenkamp View author publications You can also search for this author inPubMed Google

Scholar * Tamás Csikós View author publications You can also search for this author inPubMed Google Scholar * Anita M Klous View author publications You can also search for this author

inPubMed Google Scholar * Tom van Wezel View author publications You can also search for this author inPubMed Google Scholar * Peter Demant View author publications You can also search for

this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Peter Demant. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ruivenkamp, C.,

Csikós, T., Klous, A. _et al._ Five new mouse susceptibility to colon cancer loci, _Scc11_–_Scc15_. _Oncogene_ 22, 7258–7260 (2003). https://doi.org/10.1038/sj.onc.1207096 Download citation

* Received: 07 May 2003 * Revised: 30 July 2003 * Accepted: 07 August 2003 * Published: 16 October 2003 * Issue Date: 16 October 2003 * DOI: https://doi.org/10.1038/sj.onc.1207096 SHARE THIS

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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * susceptibility genes * colon cancer * genetic mapping * mouse genetics * AOM