Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy

ABSTRACT The clinical efficacy of anticancer nucleoside drugs depends on a complex interplay of transporters mediating entry of nucleoside drugs into cells, efflux mechanisms that remove

drugs from intracellular compartments and cellular metabolism to active metabolites. Nucleoside transporters (NTs) are important determinants for salvage of preformed nucleosides and

mediated uptake of antimetabolite nucleoside drugs into target cells. The focus of this review is the two families of human nucleoside transporters (hENTs, hCNTs) and their role in transport

of cytotoxic chemotherapeutic nucleoside drugs. Resistance to anticancer nucleoside drugs is a major clinical problem in which NTs have been implicated. Single nucleotide polymorphisms

(SNPs) in drug transporters may contribute to interindividual variation in response to nucleoside drugs. In this review, we give an overview of the functional and molecular characteristics

of human NTs and their potential role in resistance to nucleoside drugs and discuss the potential use of genetic polymorphism analyses for NTs to address drug resistance. Access through your

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BEING VIEWED BY OTHERS A SYSTEMATIC REVIEW AND META-ANALYSIS OF TOXICITY AND TREATMENT OUTCOMES WITH PHARMACOGENETIC-GUIDED DOSING COMPARED TO STANDARD OF CARE BSA-BASED FLUOROPYRIMIDINE

DOSING Article 19 March 2022 DUTCH PHARMACOGENETICS WORKING GROUP (DPWG) GUIDELINE FOR THE GENE–DRUG INTERACTION BETWEEN _UGT1A1_ AND IRINOTECAN Article 28 November 2022 ASSOCIATION OF

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Scholar  * Zimmerman TP, Mahony WB and Prus KL . (1987). _J. Biol. Chem._, 262, 5748–5754. Download references AUTHOR INFORMATION Author notes * James D Young: JDY is a Heritage Scientist of

the Alberta Heritage Foundation for Medical Research * Carol E Cass: CEC holds the Canada Research Chair in Oncology AUTHORS AND AFFILIATIONS * Membrane Protein Research Group, University

of Alberta, Canada Vijaya L Damaraju, James D Young & Carol E Cass * Department of Oncology, University of Alberta, Canada Vijaya L Damaraju, Sambasivarao Damaraju, John Mackey, Michael

B Sawyer & Carol E Cass * Department of Physiology, University of Alberta, Canada James D Young * Cross Cancer Institute, Edmonton, Alberta, T6G 1Z2, Canada Vijaya L Damaraju, 

Sambasivarao Damaraju, John Mackey, Michael B Sawyer & Carol E Cass * School of Biochemistry and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK Stephen A Baldwin Authors *

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also search for this author inPubMed Google Scholar * Carol E Cass View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence

to Carol E Cass. ADDITIONAL INFORMATION Supported by the Alberta Cancer Foundation, the Canadian Institutes of Health Research and the National Cancer Institute of Canada RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Damaraju, V., Damaraju, S., Young, J. _et al._ Nucleoside anticancer drugs: the role of nucleoside transporters in

resistance to cancer chemotherapy. _Oncogene_ 22, 7524–7536 (2003). https://doi.org/10.1038/sj.onc.1206952 Download citation * Published: 23 October 2003 * Issue Date: 20 October 2003 * DOI:

https://doi.org/10.1038/sj.onc.1206952 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * nucleoside transporters * anticancer nucleosides *

polymorphisms * SNPs * drug resistance