Vaults: a ribonucleoprotein particle involved in drug resistance?
Vaults: a ribonucleoprotein particle involved in drug resistance?"
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ABSTRACT Vaults are ribonucleoprotein particles found in the cytoplasm of eucaryotic cells. The 13 MDa particles are composed of multiple copies of three proteins: an _M_r 100 000 major
vault protein (MVP) and two minor vault proteins of _M_r 193 000 (vault poly-(ADP-ribose) polymerase) and _M_r 240 000 (telomerase-associated protein 1), as well as small untranslated RNA
molecules of approximately 100 bases. Although the existence of vaults was first reported in the mid-1980s no function has yet been attributed to this organelle. The notion that vaults might
play a role in drug resistance was suggested by the molecular identification of the lung resistance-related (LRP) protein as the human MVP. MVP/LRP was found to be overexpressed in many
chemoresistant cancer cell lines and primary tumor samples of different histogenetic origin. Several, but not all, clinico-pathological studies showed that MVP expression at diagnosis was an
independent adverse prognostic factor for response to chemotherapy. The hollow barrel-shaped structure of the vault complex and its subcellular localization indicate a function in
intracellular transport. It was therefore postulated that vaults contributed to drug resistance by transporting drugs away from their intracellular targets and/or the sequestration of drugs.
Here, we review the current knowledge on the vault complex and critically discuss the evidence that links vaults to drug resistance. Access through your institution Buy or subscribe This is
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EXOSOMAL CIRCRNAS IN TUMOUR IMMUNITY AND CANCER PROGRESSION Article Open access 09 June 2022 MOLECULAR FUNCTIONS AND THERAPEUTIC APPLICATIONS OF EXOSOMAL NONCODING RNAS IN CANCER Article
Open access 29 March 2022 TARGETING NON-CODING RNAS TO OVERCOME CANCER THERAPY RESISTANCE Article Open access 13 April 2022 ABBREVIATIONS * MVP: major vault protein * TEP1:
telomerase-associated protein * VPARP: vault poly-(ADP-ribose) polymerase * vRNA: vault RNA * LRP: lung resistance-related protein * P-gp: P-glycoprotein * MRP1: multidrug-resistance-related
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Biol. Chem._, 277, 40247–40252. Download references ACKNOWLEDGEMENTS We thank Erna Fränzel-Luiten, Martijn Schoester and George Scheffer for helpful discussions during the preparation of
this manuscript. This work was supported by a grant from the Dutch Cancer Society, # EUR 98-1754. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Hematology, Erasmus Medical
Center, PO Box 1738, Rotterdam, 3000 DR, The Netherlands Marieke H Mossink, Arend van Zon, Pieter Sonneveld & Erik AC Wiemer * Department of Pathology, Free University Medical Center,
Amsterdam, The Netherlands Rik J Scheper Authors * Marieke H Mossink View author publications You can also search for this author inPubMed Google Scholar * Arend van Zon View author
publications You can also search for this author inPubMed Google Scholar * Rik J Scheper View author publications You can also search for this author inPubMed Google Scholar * Pieter
Sonneveld View author publications You can also search for this author inPubMed Google Scholar * Erik AC Wiemer View author publications You can also search for this author inPubMed Google
Scholar CORRESPONDING AUTHOR Correspondence to Erik AC Wiemer. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mossink, M., van Zon, A., Scheper, R. _et
al._ Vaults: a ribonucleoprotein particle involved in drug resistance?. _Oncogene_ 22, 7458–7467 (2003). https://doi.org/10.1038/sj.onc.1206947 Download citation * Published: 23 October 2003
* Issue Date: 20 October 2003 * DOI: https://doi.org/10.1038/sj.onc.1206947 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link
Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * vault complex *
multidrug resistance * LRP * MVP
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