Development of t-cell lymphomas in eμ-iex-1 mice

ABSTRACT Inhibition of apoptosis or abnormal cell survival can result in tumorigenesis by facilitating the insurgence of various mutations. Immediate-early response gene X-1 (IEX-1),

protects T cells from apoptosis induced by the ligation of Fas or the T-cell receptor (TCR)/CD3 complex in E_μ_-IEX-1 mice that direct the gene expression in both T and B cell lineages under

the control of the E_μ_ enhancer. Consistent with a biased effect of IEX-1 towards T cells, E_μ_-IEX-1 mice selectively developed T-cell lymphomas in the spleen, when they aged, which may

be associated with increased levels of IEX-1 phosphorylation in T cells compared to B cells. The lymphomas were single positive (CD4+CD8−, CD4−CD8+), double positive (CD4+CD8+), or double

negative (CD4−CD8−) T cells. They resulted from aberrantly clonal expansions of T cells expressing a specific TCR, as suggested by the TCR repertoire analysis using a panel of monoclonal

antibodies recognizing TCR V_β_ chain, as well as by TCR _β_ gene rearrangements. The study provides, for the first time, unambiguous evidence of the oncogenic potential of IEX-1 in a

cell-specific manner. The animal model may help our understanding of peripheral T-cell lymphoma development. Access through your institution Buy or subscribe This is a preview of

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EXPRESSION INDUCE LYMPHOPROLIFERATIVE DISEASE AND ADULT T-CELL LEUKEMIA/LYMPHOMA Article Open access 29 November 2022 LOSS OF THYMOCYTE COMPETITION UNDERLIES THE TUMOR SUPPRESSIVE FUNCTIONS

OF THE E2A TRANSCRIPTION FACTOR IN T-ALL Article 28 December 2023 T-ALL CAN EVOLVE TO ONCOGENE INDEPENDENCE Article 22 January 2021 REFERENCES * Arlt A, Grobe O, Sieke A, Kruse ML, Folsch

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the staff in the Department of Pathology in the Texas Children's hospital for assistance in preparation of tissue sections and stimulating discussion. This work was supported by the

National Institutes of Health Grant AI45003, Research Scholar Grant RSG-01-178-01-MGO from the American Cancer Society, and a Moran foundation award (PRJ 00-114) from the Baylor College

Medicine (to MXW). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pathology, Baylor College of Medicine, Houston, 77030, TX Yujin Zhang, Milton J Finegold & Mei X Wu *

Department of Molecular and Cell Biology, Boston University Medical Center, Boston, 02118, MA, USA Yujin Zhang & Mei X Wu * Department of Hematology, Institut Cochin, INSERM U567, CNRS

UMR 8104, 27 rue du Fg St Jacques, Paris, 75014, France Françoise Porteu * Department of Microbiology and Immunology, University of Illinois, Chicago, 60612, Illinois, USA Prasad Kanteti

Authors * Yujin Zhang View author publications You can also search for this author inPubMed Google Scholar * Milton J Finegold View author publications You can also search for this author

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RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zhang, Y., Finegold, M., Porteu, F. _et al._ Development of T-cell lymphomas in E_μ_-IEX-1 mice.

_Oncogene_ 22, 6845–6851 (2003). https://doi.org/10.1038/sj.onc.1206707 Download citation * Received: 12 February 2003 * Revised: 01 April 2003 * Accepted: 02 April 2003 * Published: 09

October 2003 * Issue Date: 09 October 2003 * DOI: https://doi.org/10.1038/sj.onc.1206707 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * IEX-1 *

antiapoptosis * T-cell lymphoma * transgenic mice