Jnk activation is not required for fas-mediated apoptosis

ABSTRACT Fas ligation in the presence of cycloheximide induced Jun N-terminal kinase 1 (JNK1) and JNK2 phosphorylation, caspase activation and cell death in the IL-3-dependent cell line

BAF3. Fas-mediated apoptosis was prevented by expression of dominant negative FADD but not inhibited by IL-3. To investigate the role of JNK activation in this process, we examined cells

over-expressing a JNK-specific phosphatase M3/6. M3/6 prevented Fas stimulation of JNK, but did not affect Fas-mediated caspase activation or cell death, demonstrating that JNK activation is

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IKK-MEDIATED TRAF6 AND RIPK1 INTERACTION STIFLES CELL DEATH COMPLEX ASSEMBLY LEADING TO THE SUPPRESSION OF TNF-Α-INDUCED CELL DEATH Article 21 April 2023 REFERENCES * Boldin MP, Goncharov

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6: 606–613. Download references ACKNOWLEDGEMENTS This work was supported by the Cancer Research Campaign and by a Wellcome Trust Travelling Fellowship to Walter Low. AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Department of Immunology, University College London, Windeyer Building, 46 Cleveland Street, London, W1P 6DB, UK Walter Low & Mary Collins * Section of Gene

Function and Regulation, Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK Anna Smith & Alan Ashworth Authors * Walter Low View author

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RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Low, W., Smith, A., Ashworth, A. _et al._ JNK activation is not required for Fas-mediated apoptosis.

_Oncogene_ 18, 3737–3741 (1999). https://doi.org/10.1038/sj.onc.1202702 Download citation * Received: 02 October 1998 * Revised: 11 January 1999 * Accepted: 19 January 1999 * Published: 14

July 1999 * Issue Date: 24 June 1999 * DOI: https://doi.org/10.1038/sj.onc.1202702 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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CD95 * FADD * M3/6 * IL-3