Vascular compliance is secured under angiotensin inhibition in non-diabetic chronic kidney diseases
Vascular compliance is secured under angiotensin inhibition in non-diabetic chronic kidney diseases"
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Cardiovascular diseases constitute major cause of death in chronic kidney diseases (CKDs). We examined the effects of angiotensin inhibition either with angiotensin-converting enzyme
inhibitor or with angiotensin receptor blocker on patient prognosis and heart-ankle pulse wave velocity (haPWV) in CKDs. Randomized controlled study was performed on 102 patients with
non-diabetic CKDs. Patients were divided into two groups with or without angiotensin inhibition, and followed until death, creatinine clearance was halved or starting renal replacement
therapy, whichever occurred first. For 4 years, haPWV was assessed repeatedly in the surviving patients. While both groups showed well blood pressure control throughout 4 years (129±1 to
131±2/71±1 to 73±2 mm Hg), renal prognosis was better in angiotensin inhibition group (P
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