Differential pulse pressure response to various antihypertensive drug families

ABSTRACT Pulse pressure (PP) is emerging as a major pressure predictor of cardiac disease. The study comprised 10 185 untreated patients with essential hypertension. A total of 5395 men and

4790 women 56±13 years old, with uncomplicated essential hypertension, after a 15-day washout period and after 6 months of antihypertensive monotherapy were included. All patients included

in the final cohort were responders and had normalized their blood pressure. PP was decreased least with diuretics (−5 mm Hg) and most with angiotensin II receptor blockers (ARBs) and

calcium antagonists (−15 mm Hg), followed by angiotensin-converting enzyme inhibitors (ACEI) (−12 mm Hg) _α_- and _β_-blockers (−10 and −9 mm Hg), differentiating among antihypertensive

classes (_P_<0.001). The magnitude of PP fall was related to the degree of left ventricular (LV) mass reduction (_P_<0.001), seen best with ARBs (_r_=0.42) and least with ACEIs

(_r_=0.18). Of the antihypertensive medications used in everyday practice, PP decrease may be achieved best with ARBs and calcium antagonists, whereas diuretics confer poor response. PP was

decreased least with diuretics (−5 mm Hg) and most with ARBs and calcium channel blockers (−15 mm Hg), followed by ACEI (−12 mm Hg) _α_- and _β_-blockers (−10 and −9 mm Hg), differentiating

among antihypertensive classes (_P_<0.001). Of the antihypertensive medications used in everyday practice, PP decrease may be achieved best with ARBs and calcium antagonists. Access

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cardiovascular disease? _Hypertension_ 2005; 45: 575–579. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * 1st Department of Cardiology,

Onassis Cardiac Surgery Center, Athens, Greece E A Karpanou & D V Cokkinos * 1st Cardiology Department of Athens University, Hippokration Hospital, Athens, Greece G P Vyssoulis & C I

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author inPubMed Google Scholar * C I Stefanadis View author publications You can also search for this author inPubMed Google Scholar * D V Cokkinos View author publications You can also

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Karpanou, E., Vyssoulis, G., Stefanadis, C. _et al._ Differential pulse pressure response to various antihypertensive drug families. _J Hum Hypertens_ 20, 765–771 (2006).

https://doi.org/10.1038/sj.jhh.1002069 Download citation * Received: 30 November 2005 * Revised: 04 June 2006 * Accepted: 04 June 2006 * Published: 20 July 2006 * Issue Date: 01 October 2006

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not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * pulse pressure * left ventricular hypertrophy *

antihypertensive drugs