Differential pulse pressure response to various antihypertensive drug families
Differential pulse pressure response to various antihypertensive drug families"
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ABSTRACT Pulse pressure (PP) is emerging as a major pressure predictor of cardiac disease. The study comprised 10 185 untreated patients with essential hypertension. A total of 5395 men and
4790 women 56±13 years old, with uncomplicated essential hypertension, after a 15-day washout period and after 6 months of antihypertensive monotherapy were included. All patients included
in the final cohort were responders and had normalized their blood pressure. PP was decreased least with diuretics (−5 mm Hg) and most with angiotensin II receptor blockers (ARBs) and
calcium antagonists (−15 mm Hg), followed by angiotensin-converting enzyme inhibitors (ACEI) (−12 mm Hg) _α_- and _β_-blockers (−10 and −9 mm Hg), differentiating among antihypertensive
classes (_P_<0.001). The magnitude of PP fall was related to the degree of left ventricular (LV) mass reduction (_P_<0.001), seen best with ARBs (_r_=0.42) and least with ACEIs
(_r_=0.18). Of the antihypertensive medications used in everyday practice, PP decrease may be achieved best with ARBs and calcium antagonists, whereas diuretics confer poor response. PP was
decreased least with diuretics (−5 mm Hg) and most with ARBs and calcium channel blockers (−15 mm Hg), followed by ACEI (−12 mm Hg) _α_- and _β_-blockers (−10 and −9 mm Hg), differentiating
among antihypertensive classes (_P_<0.001). Of the antihypertensive medications used in everyday practice, PP decrease may be achieved best with ARBs and calcium antagonists. Access
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HYPERTENSION IN A LARGE COHORT OF PATIENTS WITH RESISTANT HYPERTENSION Article 31 August 2020 REFERENCES * Collins R, Peto R, MacMahon S, Hebert P, Fiebach NH, Eberlein KA _et al_. Blood
pressure, stroke and coronary heart disease. Part 2. Short term reductions in blood pressure: overview of randomized drug trials in their epidemiological context. _Lancet_ 1990; 335:
827–838. Article CAS Google Scholar * Franklin SS, Sutton-Tyrrell K, Belle SH, Weber MA, Kuller LH . The importance of pulsatile components of hypertension in predicting carotid stenosis
in older adults. _J Hypertens_ 1997; 15: 1143–1150. Article CAS Google Scholar * Liao D, Cooper L, Cai J, Toole J, Bryan N, Burke G _et al_. The prevalence and severity of white matter
lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC study. _Neuroepidemiol_ 1997; 6: 149–162. Article Google Scholar * Benetos A,
Rudnichi A, Safar M, Guize L . Pulse pressure and cardiovascular mortality in normotensive and hypertensive subjects. _Hypertension_ 1998; 32: 560–564. Article CAS Google Scholar * Fang
J, Madhavan S, Alderman MH . Pulse pressure: a predictor of cardiovascular mortality among young normotensive subjects. _Blood Pressure_ 2000; 9: 260–266. Article CAS Google Scholar *
Schram MT, Chaturvedi N, Fuller JH, Stehouwer CD . Pulse pressure is associated with age and cardiovascular disease in type 1 diabetes: the Eurodiab Prospective Complications Study. _J
Hypertens_ 2003; 21: 2035–2044. Article CAS Google Scholar * Schram MT, Kostense PJ, van Dijk RAJM, Dekker JM, Nijpels G, Bouter LM _et al_. Diabetes, pulse pressure and cardiovascular
mortality: the Hoorn Study. _J Hypertens_ 2002; 20: 1743–1751. Article CAS Google Scholar * Van Bortel L, Struijker-Boudier H, Safar ME . Pulse pressure, arterial stiffness, and drug
treatment of hypertension. _Hypertension_ 2001; 38: 914–921. Article CAS Google Scholar * Miwa Y, Tsushima M, Arima H, Kawano Y, Sasaguri T . Pulse pressure is an independent predictor
for the progression of aortic wall calcification in patients with controlled hyperlipidemia. _Hypertension_ 2004; 43: 536–540. Article CAS Google Scholar * Chobanian AV, Bakris GL, Black
HR, Cushman WC, Green LA, Izzo Jr JL _et al_. Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. National Heart, Lung, and Blood Institute;
National High Blood Pressure Education Program Coordinating Committee: seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood
pressure. _Hypertension_ 2003; 42: 1206–1252. Article CAS Google Scholar * Takami T, Shigemasa M . Efficacy of various antihypertensive agents as evaluated by indices of vascular
stiffness in elderly hypertensive patients. _Hypertens Res_ 2003; 26: 609–614. Article CAS Google Scholar * Devereaux RB, Reichek N . Echocardiographic determination of left ventricular
mass in man. Anatomic validation of the method. _Circulation_ 1977; 55: 613–618. Article Google Scholar * Franklin SS, Khan SA, Wong ND, Larson MG, Levy D . Is pulse pressure useful in
predicting risk for coronary heart disease? The Framingham Heart Study. _Circulation_ 1999; 100: 354–360. Article CAS Google Scholar * Domanski MJ, Davis BR, Pfeffer MA, Mitchell Gf .
Isolated systolic hypertension. Prognostic information provided by pulse pressure. _Hypertension_ 1999; 34: 375–380. Article CAS Google Scholar * Pastor-Barriuso R, Banegas JR, Damian J,
Appel LJ, Guallar E . Systolic blood pressure, diastolic blood pressure, and pulse pressure: an evaluation of their joint effect on mortality. _Ann Intern Med_ 2003; 139: 731–739. Article
Google Scholar * Blacher J, Safar ME . Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive subjects. _Arch Intern Med_ 2000; 160: 1085–1089. Article CAS
Google Scholar * Pannier B, Brunel P, el Aroussy W, Lacolley P, Safar ME . Pulse pressure and echocardiographic findings in essential hypertension. _J Hypertens_ 1989; 7: 127–132. Article
CAS Google Scholar * Khattar RS, Acharya DU, Kinsey C, Senior R, Lahiri A . Longitudinal association of ambulatory pulse pressure with left ventricle mass and vascular hypertrophy in
essential hypertension. _J Hypertens_ 1997; 15: 737–743. Article CAS Google Scholar * Chae CU, Pfeffer MA, Glynn RJ, Michell GF, Taylor JO, Hennekens CH . Increased pulse pressure and
risk of heart failure in the elderly. _JAMA_ 1999; 281: 634–639. Article CAS Google Scholar * Mitchell GF, Moye LA, Braunwald E, Rouleau JL, Bernstein V, Geltman EM _et al_.
Sphygmomanometrically determined pulse pressure is a powerful independent predictor of recurrent events after myocardial infarction in patients with impaired left ventricular function. SAVE
investigators. Survival and Ventricular Enlargement. _Circulation_ 1997; 96: 4254–4260. Article CAS Google Scholar * Domanski MJ, Mitchell GF, Norman JE, Exner DV, Pitt B, Pfeffer MA .
Independent prognostic information provided by sphygmomanometrically determined pulse pressure and mean arterial pressure in patients with left ventricular dysfunction. _J Am Coll Cardiol_
1999; 33: 951–958. Article CAS Google Scholar * Domanski MJ, Sutton-Tyrrell K, Mitchell GF, Faxon DP, Pitt B, Sopko G . Balloon Angioplasty Revascularization Investigation (BARI).
Determinants and prognostic information provided by pulse pressure in patients with coronary artery disease undergoing revascularization. The Balloon Angioplasty Revascularization
Investigation (BARI). _Am J Cardiol_ 2001; 87: 675–679. Article CAS Google Scholar * Danchin N, Benetos A, Lopez-Sublet M, Demicheli T, Safar M, Mourad JJ . ESCAPP Investigators. Aortic
pulse pressure is related to the presence and extent of coronary artery disease in men undergoing diagnostic coronary angiography: a multicenter study. _Am J Hypertens_ 2004; 17: 129–133.
Article Google Scholar * Dahlof B, Devereaux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U _et al_. LIFE Study Group. Cardiovascular morbidity and mortality in the Losardan Intervention
For Endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol. _Lancet_ 2002; 359: 995–1003. Article CAS Google Scholar * Hansson L, Lindholm LH, Niskaen L,
Hedner T, Niklason A, Luomanmaki K _et al_. Effect of angiotensin converting enzyme inhibitor compared with conventional therapy on cardiovascular morbidity and mortality in hypertension:
the Captopril Prevention Project (CAPPP) randomized trial. _Lancet_ 1999; 353: 611–616. Article CAS Google Scholar * The ALLHAT officers coordinators for the ALLHAT collaborative research
group. Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorothalidone; the Antihypertensive and Lipid-Lowering Treatment to prevent Heart Attack Trial
(ALLHAT). _JAMA_ 2000; 283: 1967–1975. * Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, Julius S _et al_. Effects of intensive blood pressure lowering and low-dose aspirin in
patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomized trial. HOT Study Group. _Lancet_ 1998; 351: 1755–1762. Article CAS Google Scholar *
Chang JJ, Luchsinger JA, Shea S . Antihypertensive medication class and pulse pressure in the elderly: analysis based on the Third National Health and Nutrition Examination Survey. _Am J
Med_ 2003; 115: 536–542. Article Google Scholar * Pannier B, Guerin A, London G, Asmar R, Safar M . Combination of low dose Perindopril/Indapamide versus Atenolol in the hypertensive
patient. Effects on systolic blood pressure and arterial haemodynamics. The REASON study. _Arch Mal Coeur_ 2002; 95: 11–16. PubMed Google Scholar * Polonia J, Barbosa L, Silva JA,
Maldonado J . Different influences on central and peripheral pulse pressure aortic wave reflections and pulse wave velocity of three different types of antihypertensive drugs. _Rev Port
Cardiol_ 2003; 22: 1485–1492. PubMed Google Scholar * de Simone G, Roman MJ, Alderman MH, Galderisi M, de Divitiis O, Devereaux RB . Is high pulse pressure a marker of preclinical
cardiovascular disease? _Hypertension_ 2005; 45: 575–579. Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * 1st Department of Cardiology,
Onassis Cardiac Surgery Center, Athens, Greece E A Karpanou & D V Cokkinos * 1st Cardiology Department of Athens University, Hippokration Hospital, Athens, Greece G P Vyssoulis & C I
Stefanadis Authors * E A Karpanou View author publications You can also search for this author inPubMed Google Scholar * G P Vyssoulis View author publications You can also search for this
author inPubMed Google Scholar * C I Stefanadis View author publications You can also search for this author inPubMed Google Scholar * D V Cokkinos View author publications You can also
search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to E A Karpanou. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE
Karpanou, E., Vyssoulis, G., Stefanadis, C. _et al._ Differential pulse pressure response to various antihypertensive drug families. _J Hum Hypertens_ 20, 765–771 (2006).
https://doi.org/10.1038/sj.jhh.1002069 Download citation * Received: 30 November 2005 * Revised: 04 June 2006 * Accepted: 04 June 2006 * Published: 20 July 2006 * Issue Date: 01 October 2006
* DOI: https://doi.org/10.1038/sj.jhh.1002069 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is
not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * pulse pressure * left ventricular hypertrophy *
antihypertensive drugs
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