Oxidative stress and baroreflex sensitivity in healthy subjects and patients with mild-to-moderate hypertension

ABSTRACT Decreased baroreflex sensitivity (BRS) is a prognostic marker in essential hypertension. Animal experiments suggest that decreased BRS is related to increased oxidative stress. Our

study was aimed at testing whether oxidative stress, estimated by isoprostane 15-F2t-IsoP urinary levels, is correlated to BRS variation in healthy subjects as well as in patients suffering

from essential hypertension. Urinary 15-F2t-IsoP levels and BRS were evaluated in two groups of subjects: healthy volunteers (_n_=64) and patients with untreated mild-to-moderate

hypertension (_n_=33). Data were analysed in 61 and 31 subjects, respectively, BRS analysis being impossible in three and two subjects, respectively. 15-F2t-IsoP levels were measured using

gas chromatography/mass spectrometry. BRS was measured using the sequence method [PS+/RR+ and PS−/RR−] and crossspectral analysis (CSP) (MF gain) at rest, lying down. No significant

correlation was found between basal urinary 15-F2t-IsoP levels and BRS (sequence method and CSP) in either healthy controls or hypertensive patients. Our study shows that oxidative stress is

not involved in interindividual variations of BRS in healthy subjects and patients suffering from mild-to-moderate hypertension Access through your institution Buy or subscribe This is a

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Measurement of F2-isoprostanes as an index of oxidative stress _in vivo_. _Free Radic Biol Med_ 2000; 28: 505–513. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS We

acknowledge the technical assistance of Hélène Pierre, Jean-Louis Quesada and Jocelyne Truchet. This work was supported by a grant from the French Society of Hypertension. AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Cardiology Department, Grenoble University Hospital, Grenoble, Cedex, France O Ormezzano, J-P Baguet & J-M Mallion * Laboratory of Pharmacology HP2, Grenoble

School of Medicine, Grenoble, France J-L Cracowski, J Bessard & G Bessard * Public Health Department, Grenoble University Hospital, Grenoble, Cedex, France P François Authors * O

Ormezzano View author publications You can also search for this author inPubMed Google Scholar * J-L Cracowski View author publications You can also search for this author inPubMed Google

Scholar * J-P Baguet View author publications You can also search for this author inPubMed Google Scholar * P François View author publications You can also search for this author inPubMed 

Google Scholar * J Bessard View author publications You can also search for this author inPubMed Google Scholar * G Bessard View author publications You can also search for this author

inPubMed Google Scholar * J-M Mallion View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to O Ormezzano. RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ormezzano, O., Cracowski, JL., Baguet, JP. _et al._ Oxidative stress and baroreflex sensitivity in healthy subjects

and patients with mild-to-moderate hypertension. _J Hum Hypertens_ 18, 517–521 (2004). https://doi.org/10.1038/sj.jhh.1001684 Download citation * Received: 14 October 2003 * Accepted: 17

December 2003 * Published: 12 February 2004 * Issue Date: 01 July 2004 * DOI: https://doi.org/10.1038/sj.jhh.1001684 SHARE THIS ARTICLE Anyone you share the following link with will be able

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initiative KEYWORDS * isoprostane * lipid peroxidation * oxidative stress baroreflex