Moxonidine: a review | Journal of Human Hypertension

ABSTRACT Moxonidine is an imidazoline compound which acts on I1 imidazoline ‘receptors’ in the central nervous system to reduce blood pressure. This novel mechanism of action is claimed to

lead to fewer adverse effects than the older centrally-acting agents such as clonidine. In this review we examine the drug’s pharmacology, clinical pharmacokinetics, efficacy as an

antihypertensive agent including comparative studies with pre-existing drugs, and adverse effect profile. With a growing number of effective antihypertensive agents already available to the

clinician, it is not yet clear whether moxonidine represents a significant advance in hypertension management. Access through your institution Buy or subscribe This is a preview of

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January 2024 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine and Therapeutics, University of Glasgow, and The Renal Unit, Western Infirmary, Glasgow, UK STW Morris &

 JL Reid Authors * STW Morris View author publications You can also search for this author inPubMed Google Scholar * JL Reid View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Morris, S., Reid, J. Moxonidine: a review. _J Hum Hypertens_ 11, 629–635 (1997).

https://doi.org/10.1038/sj.jhh.1000518 Download citation * Received: 01 May 1997 * Accepted: 29 June 1997 * Issue Date: 01 October 1997 * DOI: https://doi.org/10.1038/sj.jhh.1000518 SHARE

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * moxonidine * hypertension * imidazoline * I1 imidazoline receptor agonist