Group a streptococcal infections: first update on seasonal activity in england, 2022 to 2023

* UK Health Security Agency Research and analysis GROUP A STREPTOCOCCAL INFECTIONS: FIRST UPDATE ON SEASONAL ACTIVITY IN ENGLAND, 2022 TO 2023 Updated 29 June 2023 APPLIES TO ENGLAND

CONTENTS * Scarlet fever * Invasive group A streptococcal infection * Discussion * Data sources and methods * References * Acknowledgements Print this page © Crown copyright 2023 This

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Notifications and GP consultations of scarlet fever in England are higher than normal for this point in the season, after persisting later into the previous season. Notifications of

invasive group A streptococcus (iGAS) disease are following a similar trend with higher than expected levels for this time of year. Relatively high rates of iGAS in children are noted. This

may reflect increases in respiratory viruses and high levels of group A streptococcus (GAS) circulating in children. Medical practitioners have been alerted to this early increase in

incidence and elevated iGAS infection in children. Given the potential for severe presentations, it remains important that scarlet fever cases are treated promptly with antibiotics to limit

further spread and reduce risk of potential complications in cases and their close contacts. Clinicians should continue to be alert to the severe complications of GAS and maintain a high

degree of clinical suspicion when assessing patients, particularly those with preceding viral infection (including chickenpox) or close contacts of scarlet fever. As per national guidance,

prompt notification of scarlet fever cases and outbreaks to local UK Health Security Agency (UKHSA) HPTs, obtaining throat swabs (prior to commencing antibiotics) when there is uncertainty

about the diagnosis, and exclusion of cases from school or work until 24 hours of antibiotic treatment has been received, remain essential tools to limit spread. Data presented within this

seasonal activity update are based on data available as at 7 December 2022. An updated report will be published in a week on 15 December 2022. Weekly notifiable disease reports are published

each week throughout the year to update scarlet fever notification numbers. Key definitions are available at the end of the report. SCARLET FEVER Following higher than expected scarlet

fever activity during the early part of this summer in England, with a drop during August, notifications during the early part of the current season (2022 to 2023; seasons are defined from

mid-September to mid-September) are increasing again and remain above what is normally seen at this time of year (Figure 1). A total of 6,601 notifications of scarlet fever were received

from week 37 to 48 this season (2022 to 2023) in England, with 1,062 notifications received in week 48. This compares with an average of 1,774 (range 333 to 2,915) for this same period

(weeks 37 to 48) in the previous 5 years. While high for this point in the season the weekly notifications are lower than the weekly totals seen during the normal pre-pandemic peak season

(February to March) where peak weekly total was 1,988 in week 12 during the 2017 to 2018 season (Figure 1). FIGURE 1. WEEKLY SCARLET FEVER NOTIFICATIONS IN ENGLAND, BY SEASON, 2017 TO 2018

ONWARDS (WEEKS 37 TO 48) Note: In this graph the 2022 to 2023 season goes up to week 48. Recent weeks in the current season may change due to delayed notifications being received,

represented by a dotted line between week 47 and 48. Scarlet fever notifications to date this season showed considerable variation across England, ranging between 6.8 (London) and 18.0

(North West) per 100,000 population (Table 1); while this may represent differential disease transmission it may also relate to differential notifications from clinicians. TABLE 1. NUMBER

AND RATE PER 100,000 POPULATION OF SCARLET FEVER AND IGAS NOTIFICATIONS IN ENGLAND: WEEK 37 TO WEEK 48 OF THE 2022 TO 2023 SEASON REGION NUMBER OF CASES OF SCARLET FEVER RATE OF SCARLET

FEVER NUMBER OF CASES OF IGAS RATE OF IGAS East of England 708 10.6 59 0.9 East Midlands 827 17.0 49 1.0 London 611 6.8 85 0.9 North East 373 13.9 31 1.2 North West 1,326 18.0 86 1.2 South

East 1,016 11.4 121 1.4 South West 440 8.0 65 1.2 West Midlands 555 9.3 64 1.1 Yorkshire and the Humber 745 13.5 99 1.8 ENGLAND 6,601 11.7 659 1.2 INVASIVE GROUP A STREPTOCOCCAL INFECTION

Laboratory notifications of iGAS so far this season (weeks 37 to 48, 2022 to 2023) are higher than expected (Figure 2). So far this season there have been 652 notifications of iGAS disease

reported through laboratory surveillance in England, with a weekly high of 91 notifications in week 47. Laboratory notifications of iGAS are higher than recorded over the last 5 seasons for

the same weeks (average 311, range 175 to 454 notifications; Figure 2). FIGURE 2. WEEKLY LABORATORY NOTIFICATIONS OF IGAS, ENGLAND, BY SEASON, 2017 TO 2018 ONWARDS Note: In this graph, the

most recent weeks of the 2022 to 2023 season are expected to increase due to lags in reporting timelines from laboratories. The decline in the most recent week (week 48) should not be

interpreted as an actual drop in laboratory notifications: it is therefore represented by a dotted line between week 47 and 48. While high for this point in the season, the weekly laboratory

notifications are lower than the weekly totals seen during the normal pre-pandemic peak season (March to April) where the peak weekly total was 113 in week 14 during the 2017 to 2018 season

Figure 2). During the current season to date, the highest rates so far were reported in the Yorkshire and Humber region (1.8 per 100,000 population), followed by the South East (1.4 per

100,000) and North East, South West and North West regions (each 1.2 per 100,000; Table 1). The highest rate was in the 1 to 4 years age group (3.2 per 100,000), followed by those aged 75

years and over (2.9 per 100,000) and the under1-year age group (2.2 per 100,000; Table 2). TABLE 2. RATE PER 100,000 POPULATION OF IGAS NOTIFICATIONS IN ENGLAND BY AGE GROUP, WEEKS 37 TO 48

IN THE 2022 TO 2023 SEASON VERSUS THE 2017 TO 2018 SEASON Note: In this table the current 2022 to 2023 season covers weeks 37 to 48, whereas the 2017 to 18 season data covers the full

season, weeks 37 to 36. AGE GROUP (YEARS) 2022 TO 2023 SEASON (WEEKS 37 TO 48): NUMBER OF CASES 2022 TO 2023 SEASON (WEEKS 37 TO 48): RATE PER 100,000 POPULATION 2017 TO 2018 (FULL SEASON):

NUMBER OF CASES 2017 TO 2018 (FULL SEASON): RATE PER 100,000 POPULATION Aged 1 year and under 13 2.2 80 12.5 1 to 4 85 3.2 194 7.2 5 to 9 60 1.7 117 3.3 10 to 14 11 0.3 40 1.2 15 to 44 144

0.7 633 3.0 45 to 64 111 0.8 625 4.4 65 to 74 95 1.7 480 8.7 75 and over 140 2.9 792 17.0 TOTAL 659 1.2 2,967 5.3 The median age of patients with iGAS infection so far this season was 47

years (range 1 year and under, to 102 years), slightly lower than the range seen at this point in the preceding 5 seasons (age 54 to 57.5 years); 24% of iGAS infections reported so far this

season are in children (aged 10 years and under), higher than the range seen for the past 5 seasons (4% to 12%). So far this season 60 deaths have been recorded within 7 days of an iGAS

infection diagnosis (from any cause), with 38% (n=23) of the recorded deaths being in those aged 75 years and over, and 17% (n=10) in children aged 10 years and under (Table 3). The case

fatality rate to date is comparable this season to recent seasons. Elevations in rates of iGAS rates in children in this early part of this season has resulted in an increased number of

deaths over a relatively short period, with 13 deaths in children aged under 15 in weeks 37 to 48. Antimicrobial susceptibility results from routine laboratory surveillance so far this

season indicate tetracycline resistance in 22% of GAS sterile site isolates; this is lower than at this point last season (45%). Susceptibility testing of iGAS isolates against erythromycin

indicated 7% were found resistant (compared with 20% last season) and, for clindamycin, 7% were resistant at this point in the season (17% last season). Isolates remained universally

susceptible to penicillin. Analysis of iGAS isolate typing data indicate a diverse range of emm gene sequence types identified this season. The results indicate emm 1 was the most common

(30% of referrals), followed by emm 12 (17%), emm 89 (7%), emm 108 and emm 33 (each 4%). In children (aged <15 years) emm 1 and emm 12 have dominated this season, accounting for 50% and

21% respectively. TABLE 3. CASE FATALITY RATE (%) FOR DEATHS (ALL CAUSES) WITHIN 7 DAYS OF AN IGAS SPECIMEN, BY AGE GROUP IN ENGLAND FOR THE CURRENT SEASON AND THE PREVIOUS 5 SEASONS Notes.

The total may include notifications where the age was unknown. CFR = case fatality rate. The case fatality rate is the percentage of deaths within 7 days of iGAS infection diagnosis of cases

where follow-up has been possible. CFR should be interpreted with caution given the small numbers involved. The current season data (2022 to 2023) covers weeks 37 to 48. The prior season’s

covers the whole season (weeks 37 to 36). ‘Pandemic seasons’ presents data for the 2019 to 2020 and 2020 to 2021 seasons combined. AGE GROUP (YEARS) 2017 TO 2018 SEASON % CFR 2018 TO 2019

SEASON % CFR PANDEMIC SEASONS (2019/2020 AND 2020/2021) % CFR 2021 TO 2022 SEASON % CFR 2022 TO 2023 SEASON (WEEKS 37-48) % CFR 2022 TO 2023 SEASON: NUMBER OF DEATHS (ALL CAUSES) WITHIN 7

DAYS OF IGAS Aged 1 year and under 5.6% 2.1% 7.7% 3.8% 0.0% 0 1 to 4 4.7% 6.1% 9.0% 5.9% 6.0% 5 5 to 9 9.9% 4.6% 2.7% 10.6% 8.6% 5 10 to 14 7.9% 8.7% 23.8% 0.0% 27.3% 3 15 to 44 4.1% 1.7%

2.5% 2.3% 3.6% 5 45 to 64 8.4% 8.6% 9.3% 9.7% 7.5% 8 65 to 74 13.5% 8.8% 13.8% 13.1% 12.1% 11 75 and over 24.4% 16.8% 19.9% 18.1% 16.3% 23 TOTAL 12.4% 9.1% 11.3% 10.0% 9.3% 60 DISCUSSION

There continues to be a steep increase in scarlet fever notification and GP consultations early in the 2022 to 2023 season, with higher numbers than would be expected at this time of the

year. The rate of iGAS infection notifications is following a similar pattern, with weekly incidence trending slightly above what would be expected during the first part of the season,

particularly in recent weeks. While the rate of iGAS infection is elevated in all age groups, incidence in children aged under 10 has been particularly high compared to levels reported in

the last peak season preceding the COVID-19 pandemic – and substantially higher than the past 2 years. Investigations are underway following reports of an increase in lower respiratory tract

GAS infections, particularly empyema, in children over the past few weeks. The current emm types have been circulating for the last 5 years, following the documented emergence of M1UK in

2016. Detailed genomic and biological investigations are underway to investigate any differences in the pathogen being seen this season. The elevated iGAS levels in children compared to the

period when pandemic control measures were in place is likely to be a consequence of the heightened scarlet fever activity given the crossover of strains associated in both presentations (1,

2). Prompt treatment of scarlet fever with antibiotics is recommended to reduce risk of possible complications and limit onward transmission. Public health messaging to encourage contact

with NHS 111 or GP practices for clinical assessment of patients with specific symptoms (for example, rash) has been issued along with reminders to provide ‘safety netting’ advice for

parents indicating signs and symptoms of deterioration, particularly for children with respiratory viral infection. GPs and other frontline clinical staff are also reminded of the increased

risk of invasive disease among household contacts of scarlet fever cases (3, 4). At present the weekly rate of iGAS in individuals aged over 75 years is not exceeding pre-pandemic periods

and the case fatality rate is lower than previous years. Clinicians should continue to be mindful of potential increases in invasive disease and maintain a high index of suspicion in

relevant patients as early recognition and prompt initiation of specific and supportive therapy for patients with iGAS infection can be life-saving. Relevant guidelines and information can

be found on GOV.UK: * Guidelines for the public health management of scarlet fever outbreaks in schools, nurseries and other childcare settings * Scarlet fever: symptoms, diagnosis and

treatment * Guidelines for the management of close community contacts of invasive GAS cases and the prevention and control of GAS transmission in acute healthcare and maternity settings *

Weekly notifiable diseases reports are published each week for a timelier update * Blog: Group A Strep – What you need to know Invasive disease isolates and also non-invasive isolates from

suspected clusters or outbreaks should be submitted to: Staphylococcus and Streptococcus Reference Section Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI) UK Health

Security Agency 61 Colindale Avenue London NW9 5HT DATA SOURCES AND METHODS Scarlet fever notification data were extracted from the notifications of infectious diseases (NOIDs) reports, data

for England was extracted on 7 December 2022. iGAS laboratory notification data were extracted from the UK Health Security Agency Second Generation Surveillance System (SGSS) and combined

with specimen referrals to the Staphylococcus and Streptococcus Reference Section to produce a total number of episodes for England. Data were extracted 7 December 2022. A season runs from

week 37 to week 36 each year (mid-September to mid-September). All-cause deaths within +/- 7 days: Reported date of death (obtained from tracing against the NHS SPINE where patient

information is available) is compared to the date of iGAS specimen in a patient. Those where the difference between the 2 dates is ≤ plus 7 days and ≥ minus 7 days (to include those

potentially diagnosed via post mortem). Follow up was not possible for all reported iGAS cases, primarily due to poor identifier (NHS number and date of birth) completion. In addition, not

all iGAS cases have the full 7-day follow-up period for case fatality assessment. CFR should be interpreted with caution given the small numbers involved. Population rates are calculated per

100,000 using the relevant year ONS mid-year population estimate. The M protein gene (emm) encodes the cell surface M virulence protein. Prior to the COVID-19 pandemic, there were a number

of seasons with elevated incidence of scarlet fever and iGAS, in particular, the 2017 to 2018 season. This has been used as a comparison point to the trends in the current season. During the

pandemic there was an unprecedented reduction in the number of scarlet fever and iGAS notifications, affecting the 2019 to 2020 season, and the 2021 to 2022 season. REFERENCES 1. Chalker V,

Jironkin A, Coelho J, Al-Shahib A, Platt S, Kapatai G, and others (2017). ‘Genome analysis following a national increase in scarlet fever in England 2014’. BMC Genomics: volume 18 number 1,

page 224 2. Al-Shahib A, Underwood A, Afshar B, Turner CE, Lamagni T, Sriskandan S, and others (2106). Emergence of a novel lineage containing a prophage in emm/M3 group A Streptococcus

associated with upsurge in invasive disease in the UK’. mGen; volume 2 number 11 3. Lamagni T, and others (2018). ‘Resurgence of scarlet fever in England, 2014–16: a population based

surveillance study’. The Lancet Infectious Diseases: volume 18, number 2, pages 180 to 187 4. Watts V, and others (2019). ‘Increased risk for Invasive Group A Streptococcus disease for

household contacts of scarlet fever cases, England, 2011–2016’. Emerging Infectious Diseases: volume 25, number 3, pages 529 to 537 ACKNOWLEDGEMENTS These reports would not be possible

without the weekly contributions from microbiology colleagues in laboratories across England, without whom there would be no surveillance data. The support from colleagues within UKHSA, and

the AMRHAI Reference Unit in particular, is valued in the preparation of the report. Feedback and specific queries about this report are welcome via [email protected] Back to

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