Alzheimer's drug shouldn't be prescribed for cognitive impairment, without genetic test

Dnaindia

Alzheimer's drug shouldn't be prescribed for cognitive impairment, without genetic test"


Play all audios:

Loading...

US researchers have warned, Donepezil, a medication that is approved to treat people with Alzheimer's disease, should not be prescribed for people with mild cognitive impairment,


without a genetic test. US researchers have warned, Donepezil, a medication that is approved to treat people with Alzheimer's disease, should not be prescribed for people with mild


cognitive impairment, without a genetic test. Researchers from the University Of California discovered that for people who carry a specific genetic variation, the K-variant of


butyrylcholinesterase, or BChE-K donezpezil, could accelerate cognitive decline. The study has been published in Journal of Alzheimer's Disease. Mild cognitive impairment is a


transitional state between normal age-related changes in cognition and dementia. Because many people with the condition display symptoms similar to those caused by Alzheimer's disease,


some physicians prescribe donepezil, which is marketed under the brand name Donepezil was tested as a possible treatment for mild cognitive impairment in a large, federally funded study


published in 2005, but it was not approved by the FDA. Still, doctors have often prescribed the drug "off-label" -- meaning that it is not approved for that specific disorder --


for their patients with mild cognitive impairment. The researchers looked at the association between BChE-K and changes in cognitive function. Using two tests that measure cognitive


impairment, the Mini-Mental State Examination and the Clinical Dementia Rating Sum of Boxes. The findings indicated that people with the genetic variation, who were treated with donepezil


had greater changes in their scores than those who took placebos. They also found that those who took donepezil had a faster cognitive decline than those who took the placebo. The findings


reinforce the importance of physicians discussing the possible benefits and risks of this treatment with their patients. (This article has not been edited by DNA's editorial team and is


auto-generated from an agency feed.)


Trending News

Targeted modulation of immune cells and tissues using engineered biomaterials

ABSTRACT Therapies modulating the immune system offer the prospect of treating a wide range of conditions including infe...

Michelle obama embarrassment: ex-flotus mocked for 'voting squad'

The former First Lady and wife of Barack Obama announced her star-studded squad last week as part of an initiative for t...

Eddie jones’s jibe at ireland’s ‘united nations’ team

Eddie Jones turned up the heat on Ireland’s inexperienced side before tomorrow’s Autumn Nations Cup clash by questioning...

What we’ve learnt from building africa’s biggest genome library

The human genome was first sequenced in 2003 by multiple research centres across the world. The breakthrough was hailed ...

Pak gurdwara row: ‘hence need caa,’ says bjp; sonia demands action

Following reports of a mob attack on Pakistan’s Nankana Sahib Gurdwara on Friday, 3 January, political leaders across pa...

Latests News

Alzheimer's drug shouldn't be prescribed for cognitive impairment, without genetic test

US researchers have warned, Donepezil, a medication that is approved to treat people with Alzheimer's disease, shou...

Javascript support required...

The page you were looking for doesn't exist.

You may have mistyped the address or the page may have moved.By proceeding, you agree to our Terms & Conditions and our ...

Tyson fury at man utd: boxer reveals wilder fight plans, venue, date

The Gypsy King and Bronze Bomber locked horns over the weekend. But after an enthralling clash, the bout was controversi...

Looking for love? Here are 17 dating apps and websites for over-50 singles

5. COFFEE MEETS BAGEL​ (CMB) CMB encourages users to make real connections by limiting the number of profiles they can l...

Top