Retraction note: the hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Retraction of: _Nature_ https://doi.org/10.1038/nature14492 Published online 27 May 2015 The Editors have retracted this paper because, in their view, data in Extended Data Fig. 1d and

Extended Data Fig. 4a are unreliable. Issues with the original antibody used in Extended Data Fig. 1d and 4a have been identified. The western blots showing an increase in secreted LOX in

bone-trophic and hypoxic MDA-MB-231 cells, and shRNA knockdown of LOX in 4T1 cells, present unreliable bands. R.L. agrees with the retraction. All other authors disagree with the retraction

and believe the findings are still valid. AUTHOR INFORMATION Author notes * These authors contributed equally: Alison Gartland & Janine T. Erler AUTHORS AND AFFILIATIONS * Biotech

Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Copenhagen, Denmark Thomas R. Cox, Lara Perryman, Anette M. Høye, Rune Linding & Janine T. Erler * Hypoxia and

Metastasis Team, Cancer ResearchUKTumour Cell Signalling Unit, The Institute of Cancer Research, London, UK Thomas R. Cox, Demelza Bird, Georgina Lang & Janine T. Erler * The Mellanby

Centre for Bone Research, The University of Sheffield, Sheffield, UK Robin M. H. Rumney, Ankita Agrawal, Norain Ab Latif, Hamish Forrest, Holly R. Evans, Iain D. Huggins & Alison

Gartland * Cellular Signal Integration Group (C-SIG), Technical University of Denmark (DTU), Lyngby, Denmark Erwin M. Schoof & Rune Linding Authors * Thomas R. Cox View author

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CORRESPONDING AUTHORS Correspondence to Alison Gartland or Janine T. Erler. ABOUT THIS ARTICLE CITE THIS ARTICLE Cox, T.R., Rumney, R.M.H., Schoof, E.M. _et al._ Retraction Note: The hypoxic

cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. _Nature_ 617, 208 (2023). https://doi.org/10.1038/s41586-023-06048-x Download citation * Published: 17 April 2023

* Issue Date: 04 May 2023 * DOI: https://doi.org/10.1038/s41586-023-06048-x SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link

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